Stiripentol is really a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates coadministered with stiripentol for amplified or decreased consequences. CYP3A4 substrates may well call for dosage adjustment.
nelfinavir will improve the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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This information and facts should not be applied to make your mind up whether or not to take modafinil or every other drugs. Only the Health care service provider has the knowledge and instruction to decide which medicines are right for a particular affected person. This information and facts isn't going to endorse any medicine as Protected, productive, or approved for treating any affected individual or well being condition. This is certainly only a short summary of general information regarding this medicine.
In 2008, Cephalon compensated $425m and pleaded responsible to the federal prison demand associated with its promotion of off-label takes advantage of for Provigil and two other prescription drugs. ^
On the other hand, quite a bit far more analysis (which include lots of scientific experiments in people) are going to be required to substantiate this potential use, and It's not presently part of standard health care follow when treating compound use Ailments.
Consumers may currently be underneath a terrific level of worry, i.e. most cancers people or troopers in the battle discipline. A psychoneuroimmunological strategy is So required to research the multi-practical effects of modafinil.
Though the total array of modafinil’s potential drug interactions isn't nonetheless wholly identified, numerous early scientific studies have documented prospective adverse interactions between modafinil and the subsequent medications and various compounds [78, 79]:
Clopidogrel efficacy may be diminished by medications that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is entirely as a consequence of an active metabolite. Clopidogrel is metabolized to this active metabolite in part by CYP2C19. .
cenobamate will improve the stage or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Intently. Consider a dose reduction of CYP2C19 substrates, as clinically correct, when utilised concomitantly with cenobamate.
A comprehensive literature critique dependant on Ovid Medline, EMBASE, the Cochrane and PSYCHInfo databases was carried out to determine published studies on the influence of modafinil on fatigue and EDS affiliated with neurological Ailments. Look for terms applied were stated in complement S1.
Sure medicines should not be applied at or within the time of having food stuff or ingesting sure kinds of meals since interactions may well occur.
Modafinil abuse is also common between athletes, that has led to it staying officially banned for use website by Skilled athletes by the earth Anti-Doping Company
To maintain from getting Expecting, use A further method of start Manage if you are employing this medication and for just one month following your very last dose. Other varieties of beginning Regulate contain condoms, diaphragms, or contraceptive foams or jellies.